FORSCHUNG
Aktuelle Projekte
EURO-RA "Functional Genomic Approaches Targeting Arthritis"The research Network, EURO-RA, brings together leading groups in the field of Arthritis research in Europe. The main scientific goal is to capitulize the modern postgenome methodologies such as genome wide expression profiling (microarrays), proteom analysis, comparative genomics , and genome wide mutagenesis to study Rheumatoid Arthritis (RA), the most common chronic inflammatory autoimmune disease affecting the European population. RA is a systemic, inflammatory, progresseive, chronic and destructive disease affecting primarily periphal joints, and it is associated with pain, disfigurement,and varoius extraarticular manifestations (organ failures). This combined effort of 12 research groups from 9 European countries aims to identify susceptibility genes that determine the onset, progression and chronicity of autoimmune arthritis. This in turn will provide an excellent opportunity to improve our knowledge on in vivo disease mechanism and, hence, to develop more rational forms of therapy.
Finanzierung: EU
"Die Rolle von Toll like receptor in der Pathogenes der Kollagen-induzierten Arthritis"
Finanzierung: DFG
"Unravelling the protective function of UCP2 during experimental autoimmune encephalomyelitis"
Finanzierung: Hertie-Stiftung
"Identification of genes controlling the arthritis initiating lymphocyte-endothelial cell interaction: combined in vivo imaging, genetic and therapy approaches"
Finanzierung: FORUN
"Functional analysis of INPP4b, a new susceptibility gene for Experimental Autoimmune Encephalomyelitis"
Finanzierung: FORUN
"Identification of genes controlloing chronic inflammation in RA and MS"
Finanzierung: FORUN, DFG